You should never vacuum rodent droppings in your attic because vacuuming can send contaminated particles into the air

https://donovanxxlz376.brightpathdigest.com/posts/why-you-should-never-vacuum-rodent-droppings-in-your-attic-4

You should never vacuum rodent droppings in your attic because vacuuming can send contaminated particles into the air and raise the risk of exposure to rodent-borne diseases.