When choosing or editing a gaming or anime PFP, focus on a strong silhouette...

https://uniform-wiki.win/index.php/What_Are_the_Most_Common_PFP_Mistakes_That_Make_Characters_Unrecognizable%3F

When choosing or editing a gaming or anime PFP, focus on a strong silhouette and good contrast to make it pop at small sizes. Crop tightly around the face and keep backgrounds simple so details don’t get lost